Review



compound 4  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 94
      Buy from Supplier

    Structured Review

    MedChemExpress compound 4
    Compound 4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 25 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound 4/product/MedChemExpress
    Average 94 stars, based on 25 article reviews
    compound 4 - by Bioz Stars, 2026-05
    94/100 stars

    Images



    Similar Products

    compounds 1 4 against hepg2  (ATCC)
    99
    ATCC compounds 1 4 against hepg2
    Compounds 1 4 Against Hepg2, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compounds 1 4 against hepg2/product/ATCC
    Average 99 stars, based on 1 article reviews
    compounds 1 4 against hepg2 - by Bioz Stars, 2026-05
    99/100 stars
    		  Buy from Supplier
    certified reference materials  (LGC Standards)
    94
    LGC Standards certified reference materials
    Certified Reference Materials, supplied by LGC Standards, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/certified reference materials/product/LGC Standards
    Average 94 stars, based on 1 article reviews
    certified reference materials - by Bioz Stars, 2026-05
    94/100 stars
    		  Buy from Supplier
    compound sakura finetek 62550 12 amicon ultra 4 10k centrifugal filter devices merck millipore ufc801008  (Sakura Finetek)
    86
    Sakura Finetek compound sakura finetek 62550 12 amicon ultra 4 10k centrifugal filter devices merck millipore ufc801008
    Compound Sakura Finetek 62550 12 Amicon Ultra 4 10k Centrifugal Filter Devices Merck Millipore Ufc801008, supplied by Sakura Finetek, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound sakura finetek 62550 12 amicon ultra 4 10k centrifugal filter devices merck millipore ufc801008/product/Sakura Finetek
    Average 86 stars, based on 1 article reviews
    compound sakura finetek 62550 12 amicon ultra 4 10k centrifugal filter devices merck millipore ufc801008 - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier
    molecule compound rcm1 2 2 oxo 2 thiophen 2 yl ethyl sulfanyl 4 6 di thiophen 2 yl pyridine 3 carbonitrile  (Vitas-M Laboratory Ltd)
    86
    Vitas-M Laboratory Ltd molecule compound rcm1 2 2 oxo 2 thiophen 2 yl ethyl sulfanyl 4 6 di thiophen 2 yl pyridine 3 carbonitrile
    The combination of <t>RCM1-NP</t> FA and venetoclax decreases tumor growth and enhances caspase-mediated apoptosis in a murine RMS model. (A) Schematic diagram of tumor cells inoculation and treatment. The figure is created in BioRender. Merjaneh, N. (2024) https://BioRender.com/z67t342 . (B) Combination therapy significantly reduced tumor burden compared with vehicle. The mean vehicle tumor volume on day 21 was 685 mm 3 , compared with the average tumor volume of the combination therapy of 361 mm 3 . The maximum tumor diameter was 17.3×11.5 mm and the corresponding maximum tumor volume was 1,144 mm 3 . Tumor volume was measured at different time points during the experiment (P≤0.01; n=12). (C) Combination therapy inhibited proliferation, as indicated by the decreased number of Ki67-positive cells. Combination therapy increased apoptosis, shown by the increased number of (D) BAX-positive cells and (E) the number of caspase3-positive cells compared with single agents and/or vehicle. A total of five random fields per sample were used to quantify the number of Ki67, BAX and cleaved caspase 3 positive cells per group. Values are shown as mean ± SD. Scale bar, 10 μ m. * P≤0.05, ** P≤0.01, **** P≤0.0001. RMS, rhabdomyosarcoma.
    Molecule Compound Rcm1 2 2 Oxo 2 Thiophen 2 Yl Ethyl Sulfanyl 4 6 Di Thiophen 2 Yl Pyridine 3 Carbonitrile, supplied by Vitas-M Laboratory Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/molecule compound rcm1 2 2 oxo 2 thiophen 2 yl ethyl sulfanyl 4 6 di thiophen 2 yl pyridine 3 carbonitrile/product/Vitas-M Laboratory Ltd
    Average 86 stars, based on 1 article reviews
    molecule compound rcm1 2 2 oxo 2 thiophen 2 yl ethyl sulfanyl 4 6 di thiophen 2 yl pyridine 3 carbonitrile - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier
    ethylphenyl methylene 2 thioxo 4 thiazolidinone compound 10058 f4 tocris bioscience  (Tocris)
    93
    Tocris ethylphenyl methylene 2 thioxo 4 thiazolidinone compound 10058 f4 tocris bioscience
    The combination of <t>RCM1-NP</t> FA and venetoclax decreases tumor growth and enhances caspase-mediated apoptosis in a murine RMS model. (A) Schematic diagram of tumor cells inoculation and treatment. The figure is created in BioRender. Merjaneh, N. (2024) https://BioRender.com/z67t342 . (B) Combination therapy significantly reduced tumor burden compared with vehicle. The mean vehicle tumor volume on day 21 was 685 mm 3 , compared with the average tumor volume of the combination therapy of 361 mm 3 . The maximum tumor diameter was 17.3×11.5 mm and the corresponding maximum tumor volume was 1,144 mm 3 . Tumor volume was measured at different time points during the experiment (P≤0.01; n=12). (C) Combination therapy inhibited proliferation, as indicated by the decreased number of Ki67-positive cells. Combination therapy increased apoptosis, shown by the increased number of (D) BAX-positive cells and (E) the number of caspase3-positive cells compared with single agents and/or vehicle. A total of five random fields per sample were used to quantify the number of Ki67, BAX and cleaved caspase 3 positive cells per group. Values are shown as mean ± SD. Scale bar, 10 μ m. * P≤0.05, ** P≤0.01, **** P≤0.0001. RMS, rhabdomyosarcoma.
    Ethylphenyl Methylene 2 Thioxo 4 Thiazolidinone Compound 10058 F4 Tocris Bioscience, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ethylphenyl methylene 2 thioxo 4 thiazolidinone compound 10058 f4 tocris bioscience/product/Tocris
    Average 93 stars, based on 1 article reviews
    ethylphenyl methylene 2 thioxo 4 thiazolidinone compound 10058 f4 tocris bioscience - by Bioz Stars, 2026-05
    93/100 stars
    		  Buy from Supplier
    compound 4  (MedChemExpress)
    94
    MedChemExpress compound 4
    The combination of <t>RCM1-NP</t> FA and venetoclax decreases tumor growth and enhances caspase-mediated apoptosis in a murine RMS model. (A) Schematic diagram of tumor cells inoculation and treatment. The figure is created in BioRender. Merjaneh, N. (2024) https://BioRender.com/z67t342 . (B) Combination therapy significantly reduced tumor burden compared with vehicle. The mean vehicle tumor volume on day 21 was 685 mm 3 , compared with the average tumor volume of the combination therapy of 361 mm 3 . The maximum tumor diameter was 17.3×11.5 mm and the corresponding maximum tumor volume was 1,144 mm 3 . Tumor volume was measured at different time points during the experiment (P≤0.01; n=12). (C) Combination therapy inhibited proliferation, as indicated by the decreased number of Ki67-positive cells. Combination therapy increased apoptosis, shown by the increased number of (D) BAX-positive cells and (E) the number of caspase3-positive cells compared with single agents and/or vehicle. A total of five random fields per sample were used to quantify the number of Ki67, BAX and cleaved caspase 3 positive cells per group. Values are shown as mean ± SD. Scale bar, 10 μ m. * P≤0.05, ** P≤0.01, **** P≤0.0001. RMS, rhabdomyosarcoma.
    Compound 4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound 4/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    compound 4 - by Bioz Stars, 2026-05
    94/100 stars
    		  Buy from Supplier
    compound 4  (Combi-Blocks Inc)
    86
    Combi-Blocks Inc compound 4
    The combination of <t>RCM1-NP</t> FA and venetoclax decreases tumor growth and enhances caspase-mediated apoptosis in a murine RMS model. (A) Schematic diagram of tumor cells inoculation and treatment. The figure is created in BioRender. Merjaneh, N. (2024) https://BioRender.com/z67t342 . (B) Combination therapy significantly reduced tumor burden compared with vehicle. The mean vehicle tumor volume on day 21 was 685 mm 3 , compared with the average tumor volume of the combination therapy of 361 mm 3 . The maximum tumor diameter was 17.3×11.5 mm and the corresponding maximum tumor volume was 1,144 mm 3 . Tumor volume was measured at different time points during the experiment (P≤0.01; n=12). (C) Combination therapy inhibited proliferation, as indicated by the decreased number of Ki67-positive cells. Combination therapy increased apoptosis, shown by the increased number of (D) BAX-positive cells and (E) the number of caspase3-positive cells compared with single agents and/or vehicle. A total of five random fields per sample were used to quantify the number of Ki67, BAX and cleaved caspase 3 positive cells per group. Values are shown as mean ± SD. Scale bar, 10 μ m. * P≤0.05, ** P≤0.01, **** P≤0.0001. RMS, rhabdomyosarcoma.
    Compound 4, supplied by Combi-Blocks Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound 4/product/Combi-Blocks Inc
    Average 86 stars, based on 1 article reviews
    compound 4 - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier
    compound 4 octyl itaconate  (MedChemExpress)
    95
    MedChemExpress compound 4 octyl itaconate
    Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in acute myocardial injury. WT or IRG1 KO mice with acute myocardial injury were supplemented <t>with</t> <t>4-octyl</t> itaconate (4-OI) and sacrificed 18 h post LPS exposure. ( A – D ) The levels of ROS, TBARS, the GSSG/GSH ratioin cardiac tissue homogenates and serum 8-OH-dG concentration were quantified ( n = 8). ( E , F ) Representative western blots and statistical analysis of IL-1β, NLRP3, Keap1, Nrf2, HO-1 and NQO1in heart samples were displayed ( n = 4). Data are representative of two independent experiments and show mean ± SD. ( A – D ) Two-way ANOVA with Sidak multiple comparison test. ( F ) two-sided t -test.
    Compound 4 Octyl Itaconate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound 4 octyl itaconate/product/MedChemExpress
    Average 95 stars, based on 1 article reviews
    compound 4 octyl itaconate - by Bioz Stars, 2026-05
    95/100 stars
    		  Buy from Supplier
    compound 4 binding  (Molecular Dynamics Inc)
    86
    Molecular Dynamics Inc compound 4 binding
    Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in acute myocardial injury. WT or IRG1 KO mice with acute myocardial injury were supplemented <t>with</t> <t>4-octyl</t> itaconate (4-OI) and sacrificed 18 h post LPS exposure. ( A – D ) The levels of ROS, TBARS, the GSSG/GSH ratioin cardiac tissue homogenates and serum 8-OH-dG concentration were quantified ( n = 8). ( E , F ) Representative western blots and statistical analysis of IL-1β, NLRP3, Keap1, Nrf2, HO-1 and NQO1in heart samples were displayed ( n = 4). Data are representative of two independent experiments and show mean ± SD. ( A – D ) Two-way ANOVA with Sidak multiple comparison test. ( F ) two-sided t -test.
    Compound 4 Binding, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/compound 4 binding/product/Molecular Dynamics Inc
    Average 86 stars, based on 1 article reviews
    compound 4 binding - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    The combination of RCM1-NP FA and venetoclax decreases tumor growth and enhances caspase-mediated apoptosis in a murine RMS model. (A) Schematic diagram of tumor cells inoculation and treatment. The figure is created in BioRender. Merjaneh, N. (2024) https://BioRender.com/z67t342 . (B) Combination therapy significantly reduced tumor burden compared with vehicle. The mean vehicle tumor volume on day 21 was 685 mm 3 , compared with the average tumor volume of the combination therapy of 361 mm 3 . The maximum tumor diameter was 17.3×11.5 mm and the corresponding maximum tumor volume was 1,144 mm 3 . Tumor volume was measured at different time points during the experiment (P≤0.01; n=12). (C) Combination therapy inhibited proliferation, as indicated by the decreased number of Ki67-positive cells. Combination therapy increased apoptosis, shown by the increased number of (D) BAX-positive cells and (E) the number of caspase3-positive cells compared with single agents and/or vehicle. A total of five random fields per sample were used to quantify the number of Ki67, BAX and cleaved caspase 3 positive cells per group. Values are shown as mean ± SD. Scale bar, 10 μ m. * P≤0.05, ** P≤0.01, **** P≤0.0001. RMS, rhabdomyosarcoma.

    Journal: International Journal of Oncology

    Article Title: FOXM1 inhibitor, RCM-1, enhances venetoclax mediated apoptosis through downregulation of ATP2B4 in rhabdomyosarcoma

    doi: 10.3892/ijo.2026.5865

    Figure Lengend Snippet: The combination of RCM1-NP FA and venetoclax decreases tumor growth and enhances caspase-mediated apoptosis in a murine RMS model. (A) Schematic diagram of tumor cells inoculation and treatment. The figure is created in BioRender. Merjaneh, N. (2024) https://BioRender.com/z67t342 . (B) Combination therapy significantly reduced tumor burden compared with vehicle. The mean vehicle tumor volume on day 21 was 685 mm 3 , compared with the average tumor volume of the combination therapy of 361 mm 3 . The maximum tumor diameter was 17.3×11.5 mm and the corresponding maximum tumor volume was 1,144 mm 3 . Tumor volume was measured at different time points during the experiment (P≤0.01; n=12). (C) Combination therapy inhibited proliferation, as indicated by the decreased number of Ki67-positive cells. Combination therapy increased apoptosis, shown by the increased number of (D) BAX-positive cells and (E) the number of caspase3-positive cells compared with single agents and/or vehicle. A total of five random fields per sample were used to quantify the number of Ki67, BAX and cleaved caspase 3 positive cells per group. Values are shown as mean ± SD. Scale bar, 10 μ m. * P≤0.05, ** P≤0.01, **** P≤0.0001. RMS, rhabdomyosarcoma.

    Article Snippet: The small molecule compound RCM1 (2-[2-oxo-2-(thiophen-2-yl) ethyl]sulfanyl-4,6-di(thiophen-2-yl) pyridine-3-carbonitrile) was synthesized by Vitas-M Laboratory (95% purity) and dissolved in DMSO for in vitro studies.

    Techniques:

    Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in acute myocardial injury. WT or IRG1 KO mice with acute myocardial injury were supplemented with 4-octyl itaconate (4-OI) and sacrificed 18 h post LPS exposure. ( A – D ) The levels of ROS, TBARS, the GSSG/GSH ratioin cardiac tissue homogenates and serum 8-OH-dG concentration were quantified ( n = 8). ( E , F ) Representative western blots and statistical analysis of IL-1β, NLRP3, Keap1, Nrf2, HO-1 and NQO1in heart samples were displayed ( n = 4). Data are representative of two independent experiments and show mean ± SD. ( A – D ) Two-way ANOVA with Sidak multiple comparison test. ( F ) two-sided t -test.

    Journal: Scientific Reports

    Article Title: Protective role of IRG1/itaconate in acute myocardial injury: association with NLRP3 inflammasome and oxidative stress

    doi: 10.1038/s41598-026-43821-0

    Figure Lengend Snippet: Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in acute myocardial injury. WT or IRG1 KO mice with acute myocardial injury were supplemented with 4-octyl itaconate (4-OI) and sacrificed 18 h post LPS exposure. ( A – D ) The levels of ROS, TBARS, the GSSG/GSH ratioin cardiac tissue homogenates and serum 8-OH-dG concentration were quantified ( n = 8). ( E , F ) Representative western blots and statistical analysis of IL-1β, NLRP3, Keap1, Nrf2, HO-1 and NQO1in heart samples were displayed ( n = 4). Data are representative of two independent experiments and show mean ± SD. ( A – D ) Two-way ANOVA with Sidak multiple comparison test. ( F ) two-sided t -test.

    Article Snippet: The compound 4-Octyl itaconate (4-OI, #HY-112675) was sourced from MedChemExpress, USA.

    Techniques: Concentration Assay, Western Blot, Comparison